Department: Vet Molecular Medicine and Chemistry & Chem Biology. Office: C3155 Vet Medical Center & 320 Baker Laboratory. Phone: (607) 253-3888. Email: [email protected].
Apr 12, 2022 · The experimental approaches include microscopy (electron and optical), molecular genetics, biochemistry, and biophysics. Cell culture techniques are an important aspect of research in cell biology. Yeast, insect, avian, plant, and mammalian cells are under active study at Cornell. Faculty in several units are carrying out research in cell biology.
The Weill Cornell Graduate School (WCGS) programs in B iochemistry & Structural Biology, C ell & Developmental Biology, and M olecular B iology are collectively known as the BCMB Allied program and operate as an alliance. A graduate degree or doctoral degree in Molecular Biology at Weill Cornell Graduate School draws from a faculty of forty recognized globally in medical …
Website: http://bmcb.cornell.edu Email: [email protected] Phone: 607 255-2100. 107 Biotechnology Building Cornell University Ithaca, NY 14853. Concentrations by Subject. cell biology; molecular biology; Tuition. $20,800 . Application Requirements and Deadlines. Application Deadlines: Fall, Dec. 1; no spring admission. Requirements Summary:
Our graduate community is made up of committed, enthusiastic researchers who are expanding knowledge about biological processes, as well as educating and inspiring others in regard to scientific inquiry.
There are many reasons why I chose to join BMCB at Cornell for my graduate studies. I was attracted to the Graduate Field system at Cornell, which I believe helps to foster interdisciplinary and collaborative research across departments.
The Molecular Biology program offers opportunities to develop research training in the molecular pathways involved in control of cell growth, replication and responses to environmental changes. These pathways are remarkably intricate, tying together nearly all the fundamental processes of cellular metabolism.
A course list and course descriptions are available at: Courses. Lab rotations are an important component of the students' first year as well. Each student completes three laboratory rotations, which help him/her decide on a research focus and select a thesis mentor by the end of the first year.
In their first year, BCMB Allied students take the program's core curriculum courses in molecular genetics, biochemistry and structural biology, cell biology, gene structure/function, and logic and critical analysis. A course list and course descriptions are available at: Courses.
Within six months of passing the ACE, the student must submit a five-page thesis project description to the Special Committee and meet with the committee for its approval. Thereafter, the student and the committee meet together regularly - at least annually - from year two until the student's graduation.
Admissions. PhD students are admitted to the Molecular Biology program through the BCMB Allied program. Applicants are not required to take the take the Graduate Record Examination (GRE). The program encourages - but does not require - applicants to take the GRE Advanced Test in biology, chemistry, biochemistry, or cell and molecular biology.
The graduate program in the Field of Biochemistry, Molecular and Cell Biology offers a Ph.D. degree only. The goal of our program is to educate and introduce students to the fascination of this scientific area, as well as provide them with the tools necessary to succeed in it.
Candidates come from many academic backgrounds; however, matriculating students will have commonly majored in one of the many areas of biology, chemistry or physics. There are no set standards; rather we are searching for applicants who we believe can flourish in the program.
BioMG6330 covers selected aspects of the molecular biology and biochemistry of DNA, RNA, and protein synthesis, as well as the function and activity of RNA molecules. A course in biochemistry is required, and some training in genetics is highly recommended.
Highly conserved mismatch repair (MMR) systems have been identified in organisms ranging from bacteria to humans that recognize and repair base pair and small insertion/deletion mismatches that arise as the result of DNA replication errors, DNA damage, and genetic recombination. In humans, mutations in MMR genes have been correlated to both an increased mutation rate and a predisposition to a hereditary form of colorectal cancer (HNPCC). HNPCC has a high cure rate if detected early, underscoring the importance of obtaining new mechanistic understandings of mismatch repair and new diagnostic tools.#N#My current work is focused on understanding how MMR proteins identify mismatches and signal downstream factors during DNA replication and repair, and the role of genetic background in determining the penetrance of MMR mutations. 1. We are currently analyzing the behavior of single MSH and MLH complexes interacting with DNA using total internal fluorescence microscopy. These studies are aimed at distinguishing between competing models for how MSH and MLH proteins signal downstream steps in MMR. In addition, my lab is using genetic and biochemical approaches to test interactions between MMR components and the SGS1 helicase to prevent recombination between divergent DNA sequences. 2. My group is using deep sequencing technologies to examine genome-wide mutation accumulation in wild-type and MMR mutants. This work will allow us to identify mutational hotspots in yeast and humans and provide information that should help cancer researchers distinguish mutations critical for transformation to a cancer state from those that occur after transformation. 3. We are using molecular evolution approaches to study incompatibilities in MMR. This work offers new tools to identify genetic interactions in DNA repair pathways, with the overall goal of understanding the effect of genetic background on cancer susceptibility.#N#My laboratory has been funded since 1995 by GM53085. A nice aspect of our current work is that it involves long-term collaborations with a single molecule biophysicist (Eric Greene, Ilya Finkelstein), and population geneticists (Charles Aquadro). The result of these efforts is a novel set of interdisciplinary approaches to study the roles of MMR in maintaining genome stability.